Sulfotransferase is an enzyme that plays an important role in the metabolism of drugs, hormones, and other compounds in the body. It is responsible for transferring a sulfate group from a donor molecule to a target molecule, which can modify the activity and/or elimination of the target molecule.
Minoxidil is metabolized in the body by a number of enzymes, including sulfotransferases. Specifically, minoxidil undergoes sulfation by sulfotransferase enzymes, which can increase its solubility and aid in its elimination from the body. Sulfation of minoxidil is an important step in the metabolism of the drug, and failure to undergo this reaction can result in decreased efficacy and increased risk of adverse effects.
There are several different forms of sulfotransferase enzymes in the body, and genetic variations in these enzymes can affect the metabolism of minoxidil and other drugs. For example, individuals with genetic variants in the SULT1A1 gene may have altered metabolism of minoxidil and may require different dosages or monitoring for adverse effects.
Overall, sulfotransferase enzymes play an important role in the metabolism of minoxidil and can affect its efficacy and safety. It is important to consider the role of sulfotransferase enzymes in the metabolism of any drug, especially when dosages need to be adjusted or there are concerns about drug interactions or adverse effects.
SULT1A1 gene mutations play an important role in determining minoxidil response. Trichogene an Indian startup company introduced the Minoxidil Response Test to screen non responders from responders by doing a pharmacogenetic analysis of the SULT1A1 gene. This is the very easy and rapid test. Trichogene MRT is very affordable from buccal swab saliva sample we can determine non-responders of minoxidil with 100% accuracy. MRT is safe, and simple and provides valuable information to doctors for precision treatment.